Extracellular peptide production in Escherichia coli by inducible downregulation of lipoprotein Lpp via MicL sRNA

Abstract Despite its many benefits, Escherichia coli only poorly secretes recombinant proteins and peptides into the medium. This complicates downstream processing and notably contributes to the production costs of biopharmaceuticals. The permeability of production strains can be increased by deleti...

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Autori principali:	Martin Gibisch, Pawel Gorecki, Christopher Tauer, Esther Egger, Matthias Müller, Bernd Albrecht, Rainer Hahn, Gerald Striedner, Monika Cserjan-Puschmann
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer 2025-06-01
Serie:	Applied Microbiology and Biotechnology
Soggetti:	Fed-batch Outer membrane Permeability Knockdown Secretion Periplasmic peptides
Accesso online:	https://doi.org/10.1007/s00253-025-13524-z
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