Enhanced pharmacokinetic and therapeutic of GSH-responsive mPEG-b-P(HPMA)-SGI1776 conjugate for osteosarcoma

IntroductionSGI-1776 represents the first serine/threonine kinase inhibitor to be utilized in the treatment of osteosarcoma. It is severely restricted by poor aqueous solubility, short degradation half-life and severe side effect.MethodsA polymeric prodrug is prepared by covalently embedding SGI-177...

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Main Authors: Xingchen Shi, Rourou Wang, Zhenghua Zhang, Zixuan Wang, Weibing Xu, Xinhe Shi, Zhe Geng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-10-01
Colecção:Frontiers in Pharmacology
Assuntos:
SGI-1776
GSH-responsive
polymeric prodrug
osteosarcoma
pharmacokinetics
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2025.1676770/full
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