Scale-Up of the Manufacturing Process To Produce Docetaxel-Loaded mPEG-b-p(HPMA-Bz) Block Copolymer Micelles for Pharmaceutical Applications

[Image: see text] An efficient, scalable, and good manufacturing practice (GMP) compatible process was developed for the production of docetaxel-loaded poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) micelles. First, the synthesis of the mPEG-b-p(HPMA-Bz) block...

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Publicat a:Org Process Res Dev
Autors principals: Bresseleers, Jaleesa, Bagheri, Mahsa, Storm, Gert, Metselaar, Josbert M., Hennink, Wim E., Meeuwissen, Silvie A., van Hest, Jan C. M.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7493301/
https://ncbi.nlm.nih.gov/pubmed/32952390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.oprd.9b00387
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