Blood DNA methylation signature of cognitive reserve moderates the association between CSF tau pathology and memory in prodromal Alzheimer's disease

Abstract INTRODUCTION Cognitive reserve (CR) reflects variability in cognitive adaptability that modifies the impact of Alzheimer's disease (AD) pathology on cognition. However, blood‐based biomarkers of CR have not been established in prodromal AD. We operationalized CR as memory reserve, defined b...

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Detalhes bibliográficos

Principais autores:	David Lukacsovich, Juan I. Young, Lissette Gomez, Brian W. Kunkle, Zhixin Mao, Wei Zhang, X. Steven Chen, Deirdre M. O'Shea, Tatjana Rundek, Eden R. Martin, Lily Wang, for the Alzheimer's Disease Neuroimaging Initiative
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2026-04-01
coleção:	Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Assuntos:	cognitive reserve DNA methylation CSF pTau181 mild cognitive impairment Alzheimer's Disease Neuroimaging Initiative ADNI
Acesso em linha:	https://doi.org/10.1002/trc2.70257
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