Cell surface GRP78-directed CAR-T cells are effective at treating human pancreatic cancer in preclinical models
Pancreatic cancer is a highly lethal solid malignancy with limited treatment options. Chimeric antigen receptor T (CAR-T) cell therapy has been successfully applied to treat hematological malignancies, but faces many challenges in solid tumors. One major challenge is the shortage of tumor-selective...
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| Principais autores: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2024-01-01
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| Serier: | Translational Oncology |
| Fag: | |
| Online adgang: | http://www.sciencedirect.com/science/article/pii/S1936523323001894 |
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