Simvastatin attenuates the c-Raf/Erk and calcineurin-NFATc2 pathways via inhibition of Hsp90 activity during the development of heart failure

Hsp90 is a molecular chaperone that contributes to the activation and stabilization of client proteins. In our previous studies, we found that inhibition of Hsp90 delayed cardiac remodeling during the development of chronic heart failure in animal models. Simvastatin, an inhibitor of HMG-CoA reducta...

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Autors principals:	Tetsuro Marunouchi, Kyo Fujita, Kirara Takahashi, Shunsuke Namiki, Lina Kyo, Manami Uchida, Emi Yano, Kouichi Tanonaka
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2023-01-01
Col·lecció:	Journal of Pharmacological Sciences
Matèries:	Heart failure Simvastatin Hsp90 c-Raf Calcineurin Fibrosis
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S1347861322000858
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