Targeting ALDOA to modulate tumorigenesis and energy metabolism in retinoblastoma

Summary: This study aims to elucidate the pivotal role of aldolase A (ALDOA) in retinoblastoma (RB) and evaluate the potential of the ALDOA inhibitor itaconate in impeding RB progression. Utilizing single-cell RNA sequencing, ALDOA consistently exhibits overexpression across diverse cell types, part...

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Detalles Bibliográficos

Principais autores:	Yinghao Wang, Junjie Tang, Yaoming Liu, Zhihui Zhang, Hongwei Zhang, Yujun Ma, Xinyue Wang, Siming Ai, Yuxiang Mao, Ping Zhang, Shuxia Chen, Jinmiao Li, Yang Gao, Chao Cheng, Cheng Li, Shicai Su, Rong Lu
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2024-09-01
Series:	iScience
Assuntos:	Molecular biology Cancer Transcriptomics
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2589004224019503
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