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Dominant TET2 mutations predict adverse prognosis in cytogenetically normal acute myeloid leukemia patients

ObjectiveThis study aimed to characterize TET2 mutations in CN-AML, assess their clinical features, and evaluate the prognostic impact of VAF and clonal hierarchy on overall survival (OS) and relapse-free survival (RFS).MethodsA cohort of 206 adult CN-AML patients was analyzed for the presence of TE...

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Principais autores: Zhuanghui Hao, Jingjing Xia, Sicheng Bian, Miaoke Song, Miao Zhang, Jingyi Feng, Shuo Li, Huichao Wang, Yaofang Zhang, Wanfang Yang, Jianmei Chang, Fanggang Ren, Xufeng Huang, Xiuhua Chen, Hongwei Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-01-01
coleção:Frontiers in Oncology
Assuntos:
acute myeloid leukemia
co-mutations
dominant
outcome
TET2 mutation
variant allele frequency
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2025.1730830/full
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