CRISPR-Cas9 identifies growth-related subtypes of glioblastoma with therapeutical significance through cell line knockdown

Abstract Background Glioblastoma (GBM) is a type of highly malignant brain tumor that is known for its significant intratumoral heterogeneity, meaning that there can be a high degree of variability within the tumor tissue. Despite the identification of several subtypes of GBM in recent years, there...

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Главные авторы:	Nannan Zhao, Siyuan Weng, Zaoqu Liu, Hui Xu, Yuqin Ren, Chunguang Guo, Long Liu, Zhenyu Zhang, Yuchen Ji, Xinwei Han
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2023-08-01
Серии:	BMC Cancer
Предметы:	CRISPR-Cas9 Glioblastoma Tumor heterogeneity Copy number variants Precision medicine
Online-ссылка:	https://doi.org/10.1186/s12885-023-11131-7
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