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Bruton’s Tyrosine Kinase: An Emerging Key Player in Innate Immunity

Bruton’s tyrosine kinase (BTK) was initially discovered as a critical mediator of B cell receptor signaling in the development and functioning of adaptive immunity. Growing evidence also suggests multiple roles for BTK in mononuclear cells of the innate immune system, especially in dendritic cells a...

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Principais autores: Alexander N. R. Weber, Zsofia Bittner, Xiao Liu, Truong-Minh Dang, Markus Philipp Radsak, Cornelia Brunner
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017-11-01
coleção:Frontiers in Immunology
Assuntos:
Bruton’s tyrosine kinase
macrophage
dendritic cell
Toll-like receptor
NLRP3 inflammasome
ibrutinib
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01454/full
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