Bruton's Tyrosine Kinase Inhibition Attenuates the Cardiac Dysfunction Caused by Cecal Ligation and Puncture in Mice

Sepsis is one of the most prevalent diseases in the world. The development of cardiac dysfunction in sepsis results in an increase of mortality. It is known that Bruton's tyrosine kinase (BTK) plays a role in toll-like receptor signaling and NLRP3 inflammasome activation, two key components in the p...

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Principais autores:	Caroline E. O'Riordan, Gareth S. D. Purvis, Debora Collotta, Fausto Chiazza, Bianka Wissuwa, Sura Al Zoubi, Lara Stiehler, Lukas Martin, Sina M. Coldewey, Massimo Collino, Christoph Thiemermann
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-09-01
coleção:	Frontiers in Immunology
Assuntos:	Bruton's tyrosine kinase (BTK) sepsis cardiac dysfunction ibrutinib acalabrutinib NLRP3
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2019.02129/full
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