Bruton’s tyrosine kinase inhibition attenuates disease progression by reducing renal immune cell invasion in mice with hemolytic-uremic syndrome

Hemolytic-uremic syndrome (HUS) can occur as a complication of an infection with Shiga-toxin (Stx)-producing Escherichia coli. Patients typically present with acute kidney injury, microangiopathic hemolytic anemia and thrombocytopenia. There is evidence that Stx-induced renal damage propagates a pro...

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Principais autores:	Sarah Kröller, Bianka Wissuwa, Sophie Dennhardt, Nadine Krieg, Christoph Thiemermann, Christoph Daniel, Kerstin Amann, Florian Gunzer, Sina M. Coldewey
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-02-01
coleção:	Frontiers in Immunology
Assuntos:	hemolytic-uremic syndrome acute kidney injury inflammation animal model Bruton’s tyrosine kinase ibrutinib
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1105181/full
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