Folate Deficiency Triggers the Abnormal Segregation of a Region With Large Cluster of CG-Rich Trinucleotide Repeats on Human Chromosome 2

Folate deficiency is associated with a broad range of human disorders, including anemia, fetal neural tube defects, age-associated dementia and several types of cancer. It is well established that a subgroup of rare fragile sites (RFSs) containing expanded CGG trinucleotide repeat (TNR) sequences di...

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Detalhes bibliográficos

Principais autores:	Lorenza Garribba, Ivan Vogel, Mads Lerdrup, Marisa M. Gonçalves Dinis, Liqun Ren, Ying Liu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-07-01
coleção:	Frontiers in Genetics
Assuntos:	aneuploidy fluorodeoxyuridine fragile site FRAXA nondisjunction MiDAS
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fgene.2021.695124/full
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