A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line

<p>Abstract</p> <p>Background</p> <p>The Signal Transducer and Activator of Transcription 3 (STAT3) is activated in tumor cells, and STAT3-inhibitors are able to induce the death of those cells. Decoy oligodeoxynucleotides (dODNs), which bind to the DNA Binding Domain (DBD) of STAT3, are efficient i...

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Detalhes bibliográficos

Principais autores:	Souissi Inès, Ladam Patrick, Cognet Jean AH, Le Coquil Stéphanie, Varin-Blank Nadine, Baran-Marszak Fanny, Metelev Valeri, Fagard Remi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2012-03-01
coleção:	Molecular Cancer
Assuntos:	Hairpin decoy oligodeoxynucleotide (hpdODN) STAT3 STAT1 Colon carcinoma cell line
Acesso em linha:	http://www.molecular-cancer.com/content/11/1/12
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