Low T cell diversity associates with poor outcome in bladder cancer: A comprehensive longitudinal analysis of the T cell receptor repertoire

Summary: T cells are crucial effector cells in the endogenous defense against cancer, yet the clinical impact of their quantity, diversity, and dynamics remains underexplored. Here, we investigate the clinical relevance of the T cell receptor (TCR) repertoire in patients with bladder cancer. In adva...

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Detalhes bibliográficos

Principais autores:	Asbjørn Kjær, Nanna Kristjánsdóttir, Randi Istrup Juul, Iver Nordentoft, Karin Birkenkamp-Demtröder, Johanne Ahrenfeldt, Trine Strandgaard, Deema Radif, Darren Hodgson, Christopher Abbosh, Hugo J.W.L. Aerts, Mads Agerbæk, Jørgen Bjerggaard Jensen, Nicolai J. Birkbak, Lars Dyrskjøt
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-05-01
coleção:	Cell Reports Medicine
Assuntos:	T cell receptors TCR sequencing single-cell sequencing bladder cancer muscle-invasive bladder cancer biomarkers
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2666379125001740
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