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CD11b Signaling Prevents Chondrocyte Mineralization and Attenuates the Severity of Osteoarthritis

Osteoarthritis (OA) is a progressive joint disease that is strongly associated with calcium-containing crystal formation (mineralization) by chondrocytes leading ultimately to cartilage calcification. However, this calcification process is poorly understood and treatments targeting the underlying di...

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Principais autores: Driss Ehirchiou, Ilaria Bernabei, Véronique Chobaz, Mariela Castelblanco, Thomas Hügle, Alexander So, Li Zhang, Nathalie Busso, Sonia Nasi
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-12-01
Serier:Frontiers in Cell and Developmental Biology
Fag:
CD11b
integrin
calcium-containing crystals
osteoarthritis
animal model
chondrocyte mineralization
Online adgang:https://www.frontiersin.org/articles/10.3389/fcell.2020.611757/full
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