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Transcriptome Profiling of Osteoblasts in a Medaka (Oryzias latipes) Osteoporosis Model Identifies Mmp13b as Crucial for Osteoclast Activation

Matrix metalloproteases (MMPs) play crucial roles in extracellular matrix (ECM) modulation during osteoclast-driven bone remodeling. In the present study, we used transcriptome profiling of bone cells in a medaka model for osteoporosis and bone regeneration to identify factors critical for bone remo...

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Main Authors: Ranran Liu, Nurgul Imangali, Lalith Prabha Ethiraj, Tom James Carney, Christoph Winkler
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
osteoblasts
osteoclasts
matrix metalloprotease
medaka (Oryzias lapites)
osteoporosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.775512/full
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