Consequences of Making the Inactive Active Through Changes in Antisense Oligonucleotide Chemistries

Antisense oligonucleotides are short, single-stranded nucleic acid analogues that can interfere with pre-messenger RNA (pre-mRNA) processing and induce excision of a targeted exon from the mature transcript. When developing a panel of antisense oligonucleotides to skip every dystrophin exon, we foun...

Descripción completa

Detalles Bibliográficos

Autores principales:	Khine Zaw, Kane Greer, May Thandar Aung-Htut, Chalermchai Mitrpant, Rakesh N. Veedu, Sue Fletcher, Steve D. Wilton
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2019-12-01
Colección:	Frontiers in Genetics
Materias:	DMD antisense oligonucleotide locked nucleic acid locked nucleic acid/2′-O-methyl mixmer cryptic splice site
Acceso en línea:	https://www.frontiersin.org/article/10.3389/fgene.2019.01249/full
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!