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An NFκB Activity Calculator to Delineate Signaling Crosstalk: Type I and II Interferons Enhance NFκB via Distinct Mechanisms

Nuclear factor kappa B (NFκB) is a transcription factor that controls inflammation and cell survival. In clinical histology, elevated NFκB activity is a hallmark of poor prognosis in inflammatory disease and cancer, and may be the result of a combination of diverse micro-environmental constituents....

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Principais autores: Simon Mitchell, Ellen L. Mercado, Adewunmi Adelaja, Jessica Q. Ho, Quen J. Cheng, Gourisankar Ghosh, Alexander Hoffmann
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019-06-01
Serier:Frontiers in Immunology
Fag:
mathematical model
signaling crosstalk
interferon
NFκB
systems biology
translational inhibition
Online adgang:https://www.frontiersin.org/article/10.3389/fimmu.2019.01425/full
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