IRF3 Negatively Regulates Toll-Like Receptor-Mediated NF-κB Signaling by Targeting TRIF for Degradation in Teleost Fish

NF-κB signaling is tightly regulated and essential to innate and adaptive immune responses, its regulatory mechanism remains unclear in various organisms, especially teleosts. In this study, we reported that IRF3 can negatively regulate TRIF-mediated NF-κB signaling pathway. Overexpression of IRF3 c...

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Detalles Bibliográficos

Principais autores:	Xueyan Zhao, Ruixuan Huo, Xiaolong Yan, Tianjun Xu
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2018-04-01
Series:	Frontiers in Immunology
Assuntos:	IRF3 TRIF NF-κB negative regulation ubiquitination
Acceso en liña:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00867/full
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