IRF3 Negatively Regulates Toll-Like Receptor-Mediated NF-κB Signaling by Targeting TRIF for Degradation in Teleost Fish

NF-κB signaling is tightly regulated and essential to innate and adaptive immune responses, its regulatory mechanism remains unclear in various organisms, especially teleosts. In this study, we reported that IRF3 can negatively regulate TRIF-mediated NF-κB signaling pathway. Overexpression of IRF3 c...

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Hauptverfasser:	Xueyan Zhao, Ruixuan Huo, Xiaolong Yan, Tianjun Xu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2018-04-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	IRF3 TRIF NF-κB negative regulation ubiquitination
Online-Zugang:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00867/full
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