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Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation

Abstract Synucleinopathies refer to a group of disorders characterized by SNCA/α-synuclein (α-Syn)-containing cytoplasmic inclusions and neuronal cell loss in the nervous system including the cortex, a common feature being cognitive impairment. Still, the molecular pathogenesis of cognitive decline...

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Huvudupphov: Hidefumi Suzuki, Naohiro Egawa, Keiko Imamura, Takayuki Kondo, Takako Enami, Kayoko Tsukita, Mika Suga, Yuichiro Yada, Ran Shibukawa, Ryosuke Takahashi, Haruhisa Inoue
Materialtyp: Artigo
Språk:Inglês
Utgiven: BMC 2024-03-01
Serie:Molecular Brain
Ämnen:
Synucleinopathies
SNCA A53T mutation
Cortical neurons
MAPK cascade
Cognitive decline
Länkar:https://doi.org/10.1186/s13041-024-01086-6
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