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Aerosolizable Lipid Nanoparticles for Pulmonary Delivery of mRNA through Design of Experiments

Messenger RNA is a class of promising nucleic acid therapeutics to treat a variety of diseases, including genetic diseases. The development of a stable and efficacious mRNA pulmonary delivery system would enable high therapeutic concentrations locally in the lungs to improve efficacy and limit poten...

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Principais autores: Hairui Zhang, Jasmim Leal, Melissa R. Soto, Hugh D. C. Smyth, Debadyuti Ghosh
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-10-01
coleção:Pharmaceutics
Assuntos:
gene therapy
mRNA therapeutics
lipid nanoparticles
pulmonary delivery
aerosolization
Acesso em linha:https://www.mdpi.com/1999-4923/12/11/1042
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