Virus adaptation to heparan sulfate comes with capsid stability tradeoff

Because of high mutation rates, viruses constantly adapt to new environments. When propagated in cell lines, certain viruses acquire positively charged amino acids on their surface proteins, enabling them to utilize negatively charged heparan sulfate (HS) as an attachment receptor. In this study, we...

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Autori principali: Han Kang Tee, Simon Crouzet, Arunima Muliyil, Gregory Mathez, Valeria Cagno, Matteo Dal Peraro, Aleksandar Antanasijevic, Sophie Clément, Caroline Tapparel
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications Ltd 2024-12-01
Serie:eLife
Soggetti:
Enterovirus A71
heparan sulfate
uncoating
virus adaptation
virus capsid stability
Accesso online:https://elifesciences.org/articles/98441
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