Tau/PTL-1 associates with kinesin-3 KIF1A/UNC-104 and affects the motor's motility characteristics in C. elegans neurons

Tauopathies are neurodegenerative diseases based on pathological tau-aggregation including Alzheimer's disease, frontotemporal dementia (FTD) and Pick's disease. In general, cargo (e.g., β-amyloid precursor protein, tau, neurofilaments) accumulation is a commonly observed phenomenon in degenerated n...

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Detalhes bibliográficos

Principais autores:	Nai-Wen Tien, Gong-Her Wu, Chih-Chun Hsu, Chien-Yu Chang, Oliver I. Wagner
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2011-08-01
coleção:	Neurobiology of Disease
Assuntos:	Tauopathies Axonal transport Molecular motors Dynein Conventional kinesin-1 Kinesin-3
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996111001409
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