Motor domain-mediated autoinhibition dictates axonal transport by the kinesin UNC-104/KIF1A.
The UNC-104/KIF1A motor is crucial for axonal transport of synaptic vesicles, but how the UNC-104/KIF1A motor is activated in vivo is not fully understood. Here, we identified point mutations located in the motor domain or the inhibitory CC1 domain, which resulted in gain-of-function alleles of unc-...
Guardat en:
| Autors principals: | , , , , , , |
|---|---|
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science (PLoS)
2021-11-01
|
| Col·lecció: | PLoS Genetics |
| Accés en línia: | https://doi.org/10.1371/journal.pgen.1009940 |
| Etiquetes: |
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|