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Quantitative Evaluation of Intraventricular Delivery of Therapeutic Neural Stem Cells to Orthotopic Glioma

Neural stem cells (NSCs) are inherently tumor-tropic, which allows them to migrate through normal tissue and selectively localize to invasive tumor sites in the brain. We have engineered a clonal, immortalized allogeneic NSC line (HB1.F3.CD21; CD-NSCs) that maintains its stem-like properties, a norm...

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Principais autores: Margarita Gutova, Linda Flores, Vikram Adhikarla, Lusine Tsaturyan, Revathiswari Tirughana, Soraya Aramburo, Marianne Metz, Joanna Gonzaga, Alexander Annala, Timothy W. Synold, Jana Portnow, Russell C. Rockne, Karen S. Aboody
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Oncology
Assuntos:
glioma
neural stem cells
NSCs
intraventricular administration
therapeutic
drug delivery
Acceso en liña:https://www.frontiersin.org/article/10.3389/fonc.2019.00068/full
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