Integrative network toxicology, transcriptomic, and molecular docking approaches to elucidate the toxicity and mechanisms of bisphenol A in stroke

Abstract Background Bisphenol A (BPA), a widespread environmental endocrine disruptor, has raised concerns for its neurotoxic effects, yet its molecular role in stroke remains unclear. Methods BPA target genes were retrieved from ChEMBL, DrugBank, and SwissTargetPrediction. Differentially expressed...

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Detalhes bibliográficos

Principais autores:	Zhonghui Wen, Bin Hu, Qiongfang Zhang, Zhifu Sun, Hai Wang, Kun Zhang, Jingchun Pei, Ziyu Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-12-01
coleção:	BMC Pharmacology and Toxicology
Assuntos:	Bisphenol A Stroke Network toxicology Molecular docking Mitochondrial respiratory chain complex I
Acesso em linha:	https://doi.org/10.1186/s40360-025-01076-x
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