TRAFIC: statistical design and analysis plan for a pragmatic early phase 1/2 Bayesian adaptive dose escalation trial in rheumatoid arthritis

Abstract Background Adaptive model-based dose-finding designs have demonstrated advantages over traditional rule-based designs but have increased statistical complexity but uptake has been slow especially outside of cancer trials. TRAFIC is a multi-centre, early phase trial in rheumatoid arthritis i...

Повний опис

Бібліографічні деталі

Автори:	M. Cole, C. Yap, C. Buckley, W. F. Ng, I. McInnes, A. Filer, S. Siebert, A. Pratt, J. D. Isaacs, D. D. Stocken
Формат:	Artigo
Мова:	Inglês
Опубліковано:	BMC 2021-07-01
Серія:	Trials
Предмети:	CRM Dose-finding Adaptive Early-phase Clinical trial
Онлайн доступ:	https://doi.org/10.1186/s13063-021-05384-5
Теги:	Додати тег Немає тегів, Будьте першим, хто поставить тег для цього запису!