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TRAFIC: statistical design and analysis plan for a pragmatic early phase 1/2 Bayesian adaptive dose escalation trial in rheumatoid arthritis

Abstract Background Adaptive model-based dose-finding designs have demonstrated advantages over traditional rule-based designs but have increased statistical complexity but uptake has been slow especially outside of cancer trials. TRAFIC is a multi-centre, early phase trial in rheumatoid arthritis i...

Deskribapen osoa

Gorde:
Egile Nagusiak: M. Cole, C. Yap, C. Buckley, W. F. Ng, I. McInnes, A. Filer, S. Siebert, A. Pratt, J. D. Isaacs, D. D. Stocken
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BMC 2021-07-01
Saila:Trials
Gaiak:
CRM
Dose-finding
Adaptive
Early-phase
Clinical trial
Sarrera elektronikoa:https://doi.org/10.1186/s13063-021-05384-5
Etiketak: Etiketa erantsi
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