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Regioselective Synthesis of 5- and 3-Hydroxy-<i>N</i>-Aryl-1<i>H</i>-Pyrazole-4-Carboxylates and Their Evaluation as Inhibitors of <i>Plasmodium falciparum</i> Dihydroorotate Dehydrogenase

In silico evaluation of various regioisomeric 5- and 3-hydroxy-substituted alkyl 1-aryl-1<i>H</i>-pyrazole-4-carboxylates and their acyclic precursors yielded promising results with respect to their binding in the active site of dihydroorotate dehydrogenase of <i>Plasmodium falciparum</i> (<i>Pf</i>...

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Hauptverfasser: Luka Vah, Tadej Medved, Uroš Grošelj, Marina Klemenčič, Črtomir Podlipnik, Bogdan Štefane, Jernej Wagger, Marko Novinec, Jurij Svete
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-07-01
Schriftenreihe:Molecules
Schlagworte:
malaria
pyrazolones
hydrazines
dihydroorotate dehydrogenase
enzyme inhibition
Online-Zugang:https://www.mdpi.com/1420-3049/27/15/4764
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