Synthesis of novel 5-(N-Boc-N-benzyl-2-aminoethyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-3-carboxamides and their inhibition of Cathepsins B and K

Eight novel 5-(N-Boc-N-benzyl-2-aminoethyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-3-carboxamides were prepared in three steps from methyl 3-amino-1H-pyrazole-4-carboxylate and methyl 5-(benzyl(tert-butoxycarbonyl)amino)-3-oxopentanoate. The synthetic procedure comprises cyclocondensation of the...

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Bibliographic Details

Main Authors:	Branislav Lukić, Uroš Grošelj, Marko Novinec, Jurij Svete
Format:	Artigo
Language:	Inglês
Published:	Slovenian Chemical Society 2017-12-01
Series:	Acta Chimica Slovenica
Subjects:	pyrazolo[1,5-a]pyrimidines cathepsin inhibition cyclization synthesis
Online Access:	https://journals.matheo.si/index.php/ACSi/article/view/3421
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