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IgG Fc galactosylation predicts response to methotrexate in early rheumatoid arthritis

Abstract Background Methotrexate (MTX) is the standard first-line therapy in rheumatoid arthritis (RA) with variable clinical efficacy that is difficult to predict. The glycosylation status of immunoglobulin G (IgG) is altered in RA and influenced by MTX treatment. We aimed to further investigate if...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Susanna L. Lundström, Aase H. Hensvold, Dorothea Rutishauser, Lars Klareskog, A. Jimmy Ytterberg, Roman A. Zubarev, Anca I. Catrina
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2017-08-01
Schriftenreihe:Arthritis Research & Therapy
Schlagworte:
Immunoglobulin
Glycosylation
Rheumatoid arthritis
Methotrexate
Complement
Biomarker
Online-Zugang:http://link.springer.com/article/10.1186/s13075-017-1389-7
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