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The MAST kinase KIN-4 carries out mitotic entry functions of Greatwall in C. elegans

Abstract MAST-like, or Greatwall (Gwl), an atypical protein kinase related to the evolutionarily conserved MAST kinase family, is crucial for cell cycle control during mitotic entry. Mechanistically, Greatwall is activated by Cyclin B-Cdk1 phosphorylation of a 550 amino acids-long insertion in its a...

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Principais autores: Ludivine Roumbo, Batool Ossareh-Nazari, Suzanne Vigneron, Ioanna Stefani, Lucie Van Hove, Véronique Legros, Guillaume Chevreux, Benjamin Lacroix, Anna Castro, Nicolas Joly, Thierry Lorca, Lionel Pintard
Format: Artigo
Sprog:Inglês
Udgivet: Springer Nature 2025-02-01
Serier:The EMBO Journal
Fag:
Development
Mitosis
Kinase
Phosphatase
C. elegans
Online adgang:https://doi.org/10.1038/s44318-025-00364-w
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