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Molecular and therapeutic advancements in Capicua (CIC)-rearranged sarcoma

Capicua (CIC)-rearranged sarcomas are an aggressive subset of undifferentiated round cell sarcomas. CIC::DUX4, the proto-typical CIC fusion oncoprotein is associated with rapid clinical progression and chemotherapy resistance leading to poor clinical outcomes. Recent studies have identified addition...

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Bibliographic Details
Main Authors: Rovingaile Kriska M. Ponce, Cuyler Luck, Ross A. Okimoto
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1416697/full
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