Improving the immunogenicity of E. coli FimH via multivalent display on I53-50 nanoparticles

Urinary tract infections, caused primarily by uropathogenic E. coli, are a significant public health burden, affecting approximately 50% of women worldwide. The adhesin FimH is responsible for host receptor binding and is therefore a promising vaccine candidate, but prior studies showed that recombi...

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Autors principals:	Rebecca S. Cole, Natalie C. Silmon de Monerri, Jacqueline Lypowy, Christopher Ponce, Cara Kobylarz, Lily Liu, Zein Kasbo, Elizabeth Kepl, Tara Ciolino, Art Illenberger, Leslie Gallardo, Annalena Laporte, Danielle Baranova, Rashmi Ravichandran, Laurent O. Chorro, Robert G.K. Donald, Raphael Simon, Neil P. King
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-07-01
Col·lecció:	Frontiers in Immunology
Matèries:	bacterial vaccine FimH adhesin protein nanoparticle vaccines UPEC UTIs (urinary tract infections)
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1872554/full
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