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Improving the immunogenicity of E. coli FimH via multivalent display on I53-50 nanoparticles

Urinary tract infections, caused primarily by uropathogenic E. coli, are a significant public health burden, affecting approximately 50% of women worldwide. The adhesin FimH is responsible for host receptor binding and is therefore a promising vaccine candidate, but prior studies showed that recombi...

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Autori principali: Rebecca S. Cole, Natalie C. Silmon de Monerri, Jacqueline Lypowy, Christopher Ponce, Cara Kobylarz, Lily Liu, Zein Kasbo, Elizabeth Kepl, Tara Ciolino, Art Illenberger, Leslie Gallardo, Annalena Laporte, Danielle Baranova, Rashmi Ravichandran, Laurent O. Chorro, Robert G.K. Donald, Raphael Simon, Neil P. King
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2026-07-01
Serie:Frontiers in Immunology
Soggetti:
bacterial vaccine
FimH adhesin
protein nanoparticle vaccines
UPEC
UTIs (urinary tract infections)
Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1872554/full
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