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Lysosome stress response and mitochondria injury are the earliest detectable alteration in FSGS

Abstract Focal segmental glomerulosclerosis (FSGS) is a histopathologic lesion caused by a dysfunction and loss of podocytes. Podocytes as postmitotic cells, rely on lysosomes to maintain their structural and functional integrity and on mitochondria to adapt their metabolic needs. The importance of...

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Váldodahkkit: Eileen Dahlke, Jessica Promnitz, Mairon Trujillo Miranda, Makhabbat Saudenova, Gèraldine Mollet, Franziska Theilig
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Nature Portfolio 2025-10-01
Ráidu:Scientific Reports
Fáttát:
Liŋkkat:https://doi.org/10.1038/s41598-025-22622-x
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