Inhibition of discoidin domain receptor (DDR)-1 with nilotinib alters CSF miRNAs and is associated with reduced inflammation and vascular fibrosis in Alzheimer’s disease

Abstract Discoidin Domain Receptor (DDR)-1 is activated by collagen. Nilotinib is a tyrosine kinase inhibitor that is FDA-approved for leukemia and potently inhibits DDR-1. Individuals diagnosed with mild–moderate Alzheimer’s disease (AD) treated with nilotinib (versus placebo) for 12 months showed...

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Κύριοι συγγραφείς:	Max Stevenson, Rency Varghese, Michaeline L. Hebron, Xiaoguang Liu, Nick Ratliff, Amelia Smith, R. Scott Turner, Charbel Moussa
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BMC 2023-05-01
Σειρά:	Journal of Neuroinflammation
Θέματα:	Discoidin domain receptor 1 Alzheimer’s disease MicroRNAs Collagen Nilotinib Cytokines
Διαθέσιμο Online:	https://doi.org/10.1186/s12974-023-02802-0
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