Inhibition of discoidin domain receptor (DDR)-1 with nilotinib alters CSF miRNAs and is associated with reduced inflammation and vascular fibrosis in Alzheimer’s disease

Abstract Discoidin Domain Receptor (DDR)-1 is activated by collagen. Nilotinib is a tyrosine kinase inhibitor that is FDA-approved for leukemia and potently inhibits DDR-1. Individuals diagnosed with mild–moderate Alzheimer’s disease (AD) treated with nilotinib (versus placebo) for 12 months showed...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Max Stevenson, Rency Varghese, Michaeline L. Hebron, Xiaoguang Liu, Nick Ratliff, Amelia Smith, R. Scott Turner, Charbel Moussa
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-05-01
coleção:	Journal of Neuroinflammation
Assuntos:	Discoidin domain receptor 1 Alzheimer’s disease MicroRNAs Collagen Nilotinib Cytokines
Acesso em linha:	https://doi.org/10.1186/s12974-023-02802-0
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!