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Pharmacological manipulation of Sema4D by salvianolic acid A mitigates diabetic retinopathy via inhibiting PlexinB1/RhoA/ROCK/pMLC2 signaling cascade involved in endothelial dysfunction

Abstract Background Diabetic retinopathy (DR) is a leading cause of blindness. While anti-vascular endothelial growth factor (VEGF) therapy is effective, its utility is limited by variable patient response and the need for frequent injections. Therefore, identifying new therapeutic targets for DR is...

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Principais autores: Weiwei Zheng, Ling Ning, Peiliang Shen, Jing Ma, Chang Yu, Ruiqin Jia, Liwenyu Chen, Wei Zou, Yuhua Xu, Yanhong Pan, Zhonghong Wei, Qiuhong Shen, Chongjin Zhong, Aiyun Wang, Wenxing Chen, Juan Chen, Suyun Yu, Jia Li, Yin Lu, Yang Zhao
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2026-07-01
Series:Chinese Medicine
Assuntos:
Salvianolic acid A
Diabetic retinopathy
Sema4D
Astrocytes
Endothelial junctions
Liposomes
Acceso en liña:https://doi.org/10.1186/s13020-026-01468-z
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