Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase.

Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-degrading enzyme known to suppress antitumor CD8(+) T cells (TCD8). The role of IDO in regulation of antiviral TCD8 responses is far less clear. In addition, whether IDO controls both immunodominant and subdominant TCD8 is not fully understood. This...

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Hlavní autoři:	Mateusz Rytelewski, Courtney E Meilleur, Maryam Atef Yekta, Peter A Szabo, Nitan Garg, Todd D Schell, Anthony M Jevnikar, Shayan Sharif, Bhagirath Singh, S M Mansour Haeryfar
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2014-01-01
Edice:	PLoS ONE
On-line přístup:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090439&type=printable
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