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Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase.

Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-degrading enzyme known to suppress antitumor CD8(+) T cells (TCD8). The role of IDO in regulation of antiviral TCD8 responses is far less clear. In addition, whether IDO controls both immunodominant and subdominant TCD8 is not fully understood. This...

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Principais autores: Mateusz Rytelewski, Courtney E Meilleur, Maryam Atef Yekta, Peter A Szabo, Nitan Garg, Todd D Schell, Anthony M Jevnikar, Shayan Sharif, Bhagirath Singh, S M Mansour Haeryfar
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2014-01-01
Serier:PLoS ONE
Online adgang:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090439&type=printable
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