Mechanistic insights into the disaggregation of amyloid-β fibrils by EPPS via replica-exchange molecular dynamics simulations
Abstract Amyloid-β (Aβ) fibrils are considered key pathological agents in the progression of Alzheimer’s disease. Recent studies demonstrated that N-(2-hydroxyethyl)piperazine-N’-(3-propane-sulfonic acid) (EPPS) effectively disaggregates Aβ oligomers and plaques in the brains of APP/PS1 transgenic m...
Gorde:
| Egile Nagusiak: | , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
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Nature Portfolio
2026-04-01
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| Saila: | Scientific Reports |
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| Sarrera elektronikoa: | https://doi.org/10.1038/s41598-026-42391-5 |
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