Mechanistic insights into the disaggregation of amyloid-β fibrils by EPPS via replica-exchange molecular dynamics simulations
Abstract Amyloid-β (Aβ) fibrils are considered key pathological agents in the progression of Alzheimer’s disease. Recent studies demonstrated that N-(2-hydroxyethyl)piperazine-N’-(3-propane-sulfonic acid) (EPPS) effectively disaggregates Aβ oligomers and plaques in the brains of APP/PS1 transgenic m...
Enregistré dans:
| Auteurs principaux: | , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Portfolio
2026-04-01
|
| Collection: | Scientific Reports |
| Sujets: | |
| Accès en ligne: | https://doi.org/10.1038/s41598-026-42391-5 |
| Tags: |
Pas de tags, Soyez le premier à ajouter un tag!
|