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Plasma proteomics in patients with von Willebrand disease and hemophilia A highlights von Willebrand factor as main determinant of response to desmopressin treatment

Background: Desmopressin, 1-deamino-8-D-arginin vasopressin (DDAVP), is a treatment option for people with von Willebrand disease (VWD) and hemophilia A (HA) with a large interindividual variation in response. DDAVP elicits the release of von Willebrand Factor (VWF) from endothelial cells, thereby i...

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Principais autores: Jessica del Castillo Alferez, Eva R. Smit, Alexander B. Meijer, Karin Fijnvandraat, Marieke J.H.A. Kruip, Tirsa T. van Duijl, Maartje van den Biggelaar
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-03-01
Serier:Research and Practice in Thrombosis and Haemostasis
Fag:
DDAVP
hemophilia A
mass spectrometry
proteomics
von Willebrand Disease
Online adgang:http://www.sciencedirect.com/science/article/pii/S2475037925000627
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