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Inhibition of Female and Male Human Detrusor Smooth Muscle Contraction by the Rac Inhibitors EHT1864 and NSC23766

IntroductionLower urinary tract symptoms (LUTS) due to overactive bladder (OAB) are caused by spontaneous detrusor contractions. Medical treatment with muscarinic receptor antagonists or β3-adrenoceptor agonists aims to inhibit detrusor contractions, but overall results are unsatisfactory. Consequen...

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Principais autores: Bingsheng Li, Qingfeng Yu, Ruixiao Wang, Christian Gratzke, Xiaolong Wang, Annabel Spek, Annika Herlemann, Alexander Tamalunas, Frank Strittmatter, Raphaela Waidelich, Christian G. Stief, Martin Hennenberg
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-04-01
Serier:Frontiers in Pharmacology
Fag:
lower urinary tract symptoms (LUTS)
overactive bladder (OAB)
detrusor overactivity
bladder smooth muscle contraction
Rac GTPases
Online adgang:https://www.frontiersin.org/article/10.3389/fphar.2020.00409/full
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