Inhibition of Female and Male Human Detrusor Smooth Muscle Contraction by the Rac Inhibitors EHT1864 and NSC23766

IntroductionLower urinary tract symptoms (LUTS) due to overactive bladder (OAB) are caused by spontaneous detrusor contractions. Medical treatment with muscarinic receptor antagonists or β3-adrenoceptor agonists aims to inhibit detrusor contractions, but overall results are unsatisfactory. Consequen...

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Detalhes bibliográficos

Principais autores:	Bingsheng Li, Qingfeng Yu, Ruixiao Wang, Christian Gratzke, Xiaolong Wang, Annabel Spek, Annika Herlemann, Alexander Tamalunas, Frank Strittmatter, Raphaela Waidelich, Christian G. Stief, Martin Hennenberg
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-04-01
coleção:	Frontiers in Pharmacology
Assuntos:	lower urinary tract symptoms (LUTS) overactive bladder (OAB) detrusor overactivity bladder smooth muscle contraction Rac GTPases
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fphar.2020.00409/full
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