Metabolic insights into phosphofructokinase inhibition in bloodstream-form trypanosomes

Previously, we reported the development of novel small molecules that are potent inhibitors of the glycolytic enzyme phosphofructokinase (PFK) of Trypanosoma brucei and related protists responsible for serious diseases in humans and domestic animals. Cultured bloodstream-form trypanosomes, which are...

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Autors principals:	Zandile Nare, Tessa Moses, Karl Burgess, Achim Schnaufer, Malcolm D. Walkinshaw, Paul A. M. Michels
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2023-02-01
Col·lecció:	Frontiers in Cellular and Infection Microbiology
Matèries:	Trypanosoma phosphofructokinase mode of inhibition metabolomics glycolytic metabolites ATP production
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fcimb.2023.1129791/full
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