A single gene mutation predicts response to immune checkpoint blockade in ovarian clear cell carcinoma

There is a lack of genetic biomarkers for predicting response to immune checkpoint blockade (ICB) therapy in cancer. The recent discovery that loss‐of‐function mutations in the gene encoding the protein phosphatase 2A (PP2A) scaffold protein PPP2R1A confer sensitivity to immune checkpoint blockade i...

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Bibliographic Details
Main Authors: Matheus Henrique Dias, René Bernards
Format: Artigo
Language:Inglês
Published: Wiley 2025-09-01
Series:Molecular Oncology
Subjects:
biomarker
Immune checkpoint blockade
ovarian cancer
Protein Phosphatase 2A
Online Access:https://doi.org/10.1002/1878-0261.70104
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